Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells
نویسندگان
چکیده
منابع مشابه
Osteopontin expression by CD103- dendritic cells drives intestinal inflammation.
Intestinal CD103(-) dendritic cells (DCs) are pathogenic for colitis. Unveiling molecular mechanisms that render these cells proinflammatory is important for the design of specific immunotherapies. In this report, we demonstrated that mesenteric lymph node CD103(-) DCs express, among other proinflammatory cytokines, high levels of osteopontin (Opn) during experimental colitis. Opn expression by...
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Tolerogenic dendritic cells (DCs) play an important role in maintaining peripheral tolerance through the induction/activation of regulatory T cells (Treg). Endogenous factors contribute to the functional development of tolerogenic DCs. In this report, we present evidence that two known immunosuppressive neuropeptides, the vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-a...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2010
ISSN: 0014-2980
DOI: 10.1002/eji.200939957