منابع مشابه
Intestinal Folate Absorption
and 2%, respectively, was converted to 5-AMeFH4. In contrast, less than 4% of the folate transferred across ileal mucosa was 5-MeFH4 when the initial mucosa concentration was 20 nM. Specific activity of dihydrofolate (DHF) reductase, the enzyme responsible for converting PGA to tetrahydrofolic acid, was measured in villus homogenates and was significantly greater in the jejunum than in the ileu...
متن کاملFolate absorption
Folic acid, or pteroylglutamic acid, is the parent substance of a large group of related compounds called 'folates'. All folate compounds have the same basic molecular structure consisting of three parts: pteridine, para-aminobenzoate (these two together forming a pteroyl group), and L-glutamic acid (Fig. 1). Pteroylglutamic acid itself is a stable, watersoluble compound with a molecular weight...
متن کاملINTESTINAL ZINC ABSORPTION IN DESFERROXAMINE-TREATED RATS
Desferroxamine (Desferal) is used tochelate iron in thalassemia, a disease of very high prevalence in various parts of lran. We have investigated intestinal zinc absorption in Desferal-treated rats which, in pilot experiments, showed low serum levels of both iron and zinc. Intraperitoneal administration of ten 0.5 g doses of Desferal (one injection every other day) to male rats produced sev...
متن کاملFormylation of folate as step in physiological folate absorption.
Oral administration of folate analogues to rats is followed by a rise in plasma folate detectable only by micro-biological assay with Lactobacillus casei, suggesting methylation of folate during absorption. When using the everted rat gut technique with folate (PteGlu), dihydrofolate (H(2)PteGlu), or tetrahydrofolate (H(4)PteGlu) on the mucosal surface formyl folate (10-CHO-PteGlu, 10-CHO-H(4)Pt...
متن کاملObservations on folate absorption with particular reference to folate polyglutamate and possible inhibitors to its absorption.
A test system for detection of inhibitors to the enzyme which removes the glutamic acid peptide chain from folate polyglutamates (folate conjugase) is described. This utilizes the reaction between plasma conjugase and the folate polyglutamate in red blood cell haemolysate. Diphenylhydantoin and yeast extracts did not inhibit plasma conjugase. The better absorption of monoglutamate forms of fola...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1971
ISSN: 0021-9738
DOI: 10.1172/jci106683