Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose

Aim: We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity female rats fed with fructose. Methods: Female Wistar (8-wk old) were divided into: sedentary (SD), (CTR), and (ITR). Moderate intensity protocols consisted running 3 days/week for 7 weeks. CTR ran 40 min at 30%–40% maximal speed (MS) TRI sets 1 70% MS followed by 35% MS. Animals standard chow fructose (10%) in drinking water. Concentration-response curves to acetylcholine phenylephrine, oxidative stress biomarkers, determined aorta. Body weight gain, visceral fat, plasma triglycerides glucose also evaluated. Results: Endothelium-dependent relaxation was significantly increased both regimens (CTR: Emax = 85 ± 6% ITR: 84 1%) compared (SD: 62 5%). The contractile response not different but phenylephrine potency (pEC50: 8.41 0.19) reduced ITR 7.06 0.11) SD 7.77 0.08). In addition, generation superoxide lower trained groups as (about −28% −22% ITR). TBARS nitrate/nitrite levels modified. Compared group, gained 39% less body has 29% fat. Glucose Conclusion: ITR, carried out days/week, efficient improve endothelium-dependent reduce aorta from