Interrupting Neuron—Tumor Interactions to Overcome Treatment Resistance

anthelmintics resistance; how to overcome it?

many parasitic helminthes of veterinary importance have genetic features that favor development of anthelmintic resistance, this becoming a major worldwide constrain in livestock production. the de-velopment of anthelmintic resistance poses a large threat to future production and welfare of grazing animals. development of variable degrees of resistance among different species of gastrointestina...

Strategies to overcome biofilm resistance

Biofilm have been found to be involved in a wide variety of microbial infections in the body, by one estimate 80% of all infections. A number of anti-biofilm strategies have emerged to prevent the colonization and formation of biofilms. However, there are four main intervention strategies in clinical practice for biofilm-associated infections. The first strategy is to prevent the initial microb...

The Causes of Resistance to Change and Solutions to Overcome It: A Review of Literature

Introduction: Technological advances as well as science and information explosion necessitate the change in students’ educational needs and in the education system. Researchers consider resistance to change as one of the major causes of the failure of changes. Therefore, the purpose of this review study was to identify the causes of resistance to change and provide solutions to overcome it. Met...

BETting on combination to overcome PARPi resistance

Targeting Notch to overcome radiation resistance

Radiotherapy represents an important therapeutic strategy in the treatment of cancer cells. However, it often fails to eliminate all tumor cells because of the intrinsic or acquired treatment resistance, which is the most common cause of tumor recurrence. Emerging evidences suggest that the Notch signaling pathway is an important pathway mediating radiation resistance in tumor cells. Successful...