Intermolecular radical carboamination of alkenes
نویسندگان
چکیده
منابع مشابه
Rh-Catalyzed Intermolecular Syn-Carboamination of Alkenes via a Transient Directing Group
Alkenes are the most ubiquitous pro-chiral functional groups accessible to synthetic chemists. For this reason, difunctionalization reactions of alkenes are particularly important, as they can be used to access highly complex molecular architectures.1,2 Stereoselective oxidation reactions, including dihydroxylation, aminohydroxylation and halogenation reactions,3,4,5,6 are well-established meth...
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A copper-catalyzed Markovnikov-type intermolecular azidocyanation of aryl alkenes has been developed to give a series of α-azido-propanenitriles in moderate to good yields. This method may provide a potential strategy for the synthesis of corresponding 3-amino-2-arylpropanoic acid.
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Ethylene, alpha-olefins, and vinyl arenes undergo platinum-catalyzed hydroarylation with substituted indoles in moderate to good yield.
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Difunctionalization of alkenes has become a powerful tool for quickly increasing molecular complexity in synthesis. Despite significant progress in the area of alkene difunctionalization involving the incorporation of a nitrogen atom across the C-C double bonds, approaches for the direct 1,2-carboamination of alkenes to produce linear N-containing molecules are scarce and remain a formidable ch...
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A Pd-catalyzed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ generation, or preformation, of a palladium tosylate emerges as a key parameter in gaining the requisite reactivity for the C-H insertion/carbopalladation/nucleophilic displacement process.
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ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2020
ISSN: 0306-0012,1460-4744
DOI: 10.1039/c9cs00692c