Intermittent fasting and probiotics in non-alcoholic fatty liver in rats: interplay between FGF19 and FGF21

Probiotics (PR) and intermittent fasting (IF) are believed to alleviate dysbiosis, which contributes Non-alcoholic fatty liver disease (NAFLD) pathogenesis. Our study investigated the effect of PR, IF, their combination (IP) on in a rat model induced by high-fat diet (HFD) We used 40 male rats, were randomly assigned one five groups: control (fed standard chow), HFD for 12 weeks), PR (HFD weeks + probiotics (a daily dose 10 × 109 CFU orally last 4 IF alternate day (ADF) IP orally) ADF weeks). Serum enzymes, lipids, HOMA-IR score considerably lower groups than group. These changes reflected pathological view. noticeably upregulated serum FGF19, hepatic FGF21, reduced Lipopolysaccharides (LPS) flavin containing dimethylaniline monoxygenase 3 (FMO3), indicating improvement gut dysbiosis suggestive hepatoprotective impact NAFLD via modulating.