Intermittent Bolus Feeding Increases Visceral Tissue Protein Synthesis More Than Continuous Feeding in Neonatal Pigs
نویسندگان
چکیده
منابع مشابه
Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs.
Infants unable to maintain oral feeding can be nourished by orogastric tube. We have shown that orogastric continuous feeding restricts muscle protein synthesis compared with intermittent bolus feeding in neonatal pigs. To determine whether leucine infusion can be used to enhance protein synthesis during continuous feeding, neonatal piglets received the same amount of formula enterally by oroga...
متن کاملAnabolic Signaling and Protein Deposition Are Enhanced by Intermittent as Compared 1 with Continuous Feeding in Skeletal Muscle of Neonates 2 Running title : Intermittent feeding increases muscle protein
20 Orogastric tube feeding is indicated for neonates with impaired ability to ingest, and can 21 be administered by intermittent bolus or continuous schedule. Our aim was to determine 22 whether feeding modalities affect muscle protein deposition and to identify mechanisms 23 involved. Neonatal pigs were overnight fasted (FAS) or fed the same amount of food 24 continuously (CON) or intermittent...
متن کاملFeeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process.
Protein synthesis is repressed in both skeletal muscle and liver after a short-term fast and is rapidly stimulated in response to feeding. Previous studies in rats and pigs have shown that the feeding-induced stimulation of protein synthesis is associated with activation of the 70-kDa ribosomal protein S6 kinase (S6K1) as well as enhanced binding of eukaryotic initiation factor eIF4E to eIF4G t...
متن کاملDifferential effects of insulin on peripheral and visceral tissue protein synthesis in neonatal pigs.
We recently demonstrated in neonatal pigs that, with amino acids and glucose maintained at fasting levels, the stimulation of protein synthesis in longissimus dorsi muscle with feeding can be reproduced by a physiological rise in insulin alone. In the current report, we determine whether the response of protein synthesis to insulin in the neonatal pig is 1) present in muscles of different fiber...
متن کاملComparison of Continuous and Intermittent Feeding Methods in Low Birth Weight Infants
Objective About 1 % of infants are of very low birth weight. However, they comprise about 50% of infant mortality. We compare the effects of continuous versus intermittent feeding on physical growth, gastrointestinal tolerance and macronutrient retention in low birth weight infants (Methods A prospective randomized trial clinical trial was performed from 2004-2005. Very low birth weight neonate...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2011
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.25.1_supplement.233.1