Intermembrane transfer of squalene promoted by supernatant protein factor
نویسندگان
چکیده
منابع مشابه
Supernatant protein factor facilitates intermembrane transfer of squalene.
Squalene epoxidation of microsome-associated squalene is stimulated by a soluble protein termed "supernatant protein factor" (SPF) (Saat, Y. A., and Bloch, K. E. (1976)J. Biol. Chem. 251, 5155-5160). In the absence of SPF, the initial rate for microsome-bound squalene epoxidation is rapid for 5 to 10 min but falls off sharply thereafter. SPF does not affect the rapid initial epoxidation rate of...
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Squalene epoxidase, a membrane-associated enzyme that converts squalene to squalene 2,3-oxide, plays an important role in the maintenance of cholesterol homeostasis. In 1957, Bloch and colleagues identified a factor from rat liver cytosol termed "supernatant protein factor (SPF)," which promotes the squalene epoxidation catalyzed by rat liver microsomes with oxygen, NADPH, FAD, and phospholipid...
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15 صفحه اولLiver Supernatant or Sterol Carrier Protein1 in the Enzymatic Conversion of Farnesyl Pyrophosphate to Squalene by Rat Liver Microsomes*
Earlier studies (Rilling, H. C. (1972) Biochem. Biophys. Res. Commun. 46, 470-475) suggested the possibility that a sterol carrier protein participated in the enzymatic conversion of farnesyl pyrophosphate to squalene by liver microsomal membranes. In the present article the possible requirement for soluble proteins in liver 105,000 x g supernatant (Slos) in the enzymatic conversion of farnesyl...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1983
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)37980-3