Interleukins 17 and 23 Influence the Host Response toHistoplasma capsulatum
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چکیده
منابع مشابه
Interleukins 17 and 23 influence the host response to Histoplasma capsulatum.
Host defenses against Histoplasma capsulatum require the action of several cytokines. Here, we explored the influence of interleukin (IL)-17 and IL-23 on immunity to H. capsulatum infection in mice. In lungs, synthesis of IL-17 was up-regulated during acute infection, and the cells producing it were predominantly CD3(+). Neutralization of IL-17A blunted fungal clearance but did not promote prog...
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Galectin-3 (gal3) is known for its immunoregulatory functions in infectious, autoimmune, and inflammatory diseases. However, little is known about its regulatory role in the host's IL-17A response to infection. Using a mouse model of histoplasmosis in which both Th1 and Th17 responses contribute to fungal clearance, we investigated how gal3 regulates IL-17A responses. Our study showed that Hist...
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Histoplasma capsulatum is a pathogenic fungus that has caused infections in all continents except Antarctica although most disease is found within the Americas. It produces a broad spectrum of illness that can on occasion be fatal. Understanding the interaction between the host and the fungus provides insights into the pathogenic mechanisms as well as the host response to replicating fungi. Thi...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2009
ISSN: 0022-1899,1537-6613
DOI: 10.1086/599333