Interleukin‐6 signaling requires only few IL‐6 molecules: Relation to physiological concentrations of extracellular IL‐6

Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade.

Anti-VEGF therapies benefit several cancer types, but drug resistance that limits therapeutic response can emerge. We generated cell lines from anti-VEGF-resistant tumor xenografts to investigate the mechanisms by which resistance develops. Of all tumor cells tested, only A431 (A431-V) epidermoid carcinoma cells developed partial resistance to the VEGF inhibitor aflibercept. Compared with the p...

IL6 to the rescue.

In addition to classic homeostatic granulocyte production mediated by G-CSF and GM-CSF, an independent pathway stimulated by IL6 complexed with its soluble receptor (sIL6R) contributes to emergency granulopoiesis.

TNFα, IL6 and EGF up-regulate GSTA4

P03-016 - ANTI IL1 refractory CINCA respondes to ANTI IL6

Case Report A 13 year old boy from a healthy non-consanguineous family suffers from severe autoinflammatory symptoms (persistent fever, polyserositis, urticaria, arthritis, developmental delay, deafness and hepatosplenomegaly) since his first year of life. Based on clinical presentation and genotype (heterozygous mutation (CAG)>Lysin (AAG)-p. Gln703Lys/Q705K substitution in Exon 3 of NLPR3) he ...

IL6 plasma concentrations in patients with sepsis receiving SLED and antibiotics: a predictor for survival.

BACKGROUND The present study evaluated interleukin-6 (IL6) as a predictor of mortality in patients and sepsis with acute kidney injury (AKI) receiving sustained low-efficiency dialysis (SLED) and antibiotic therapy. PATIENTS AND METHODS Seven patients with sepsis receiving antibiotics and SLED for AKI were studied. Blood was obtained at baseline prior to SLED and antibiotics, during SLED, and...