Interleukin-6 and C-reactive protein/albumin ratio as predictors of COVID-19 severity and mortality

Abstract Background Coronavirus disease 2019 (COVID-19) was announced in early December 2019. The pandemic situation is declared. This study aimed to evaluate the role of biomarkers estimating severity and predicting prognosis COVID-19. Results A total 116 confirmed patients were included this study. evaluated clinically. assessed. measured calculated laboratory tests done. primary outcome 30-day mortality. Patients assigned severe (14.7%) non-severe (85.3%) groups. At IL-6 level 32.3 pg/mL (the highest Youden’s index = 0.77), can differentiate from with 82.4% sensitivity 94.4% specificity. predict [odds ratio 87.7 (95% CI 18.9-408.2) ( P < 0.0001)]. After adjustment significant clinical parameters, had an adjusted odds 30.8 1.1-728.3) 0.046). high CRP/albumin > 11.4 associated COVID-19 mortality [hazard 59.9 7.4–488.3) High hazard 26.5 2.6-270.7) after age presence co-morbidities 0.006). Conclusion could effectively discriminate severity. independent risk factor for rate seem be valuable evaluating COVID-19, respectively.