Interleukin-21: A New Mediator of Inflammation in Systemic Lupus Erythematosus
نویسندگان
چکیده
منابع مشابه
Interleukin-21: A New Mediator of Inflammation in Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Pathogenesis of SLE is complex and not fully understood. There is however evidence that B and T cells are critical to the development of disease, and that T cell-derived cytokines are involved in the SLE-associated inflamm...
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OBJECTIVE The aetiology of systemic lupus erythematosus (SLE) is incompletely understood. Both genetic and environmental factors are implicated in the pathogenesis of the disease. Herein, we describe genetic association between SLE and polymorphisms in the interleukin (IL)-21 gene. The reported effect of IL-21 on B-cell differentiation into plasma cells and its effect on dendritic cell maturati...
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SUMMARY During the course of systemic lupus erythematosus in a 10 year-old girl, a go it er develo ped. Subc linical I ly pothyrnic.Jism was found, in addition rising titer of ant imicrosomal antibody and overt hypothyroidism after 6-week cessation of thyroxin tablet lead to the diagnosis of Hashimoto's thyroiditis. Antibodies directed to the thyroid may result in an autoimmune thyroiditis in...
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ژورنال
عنوان ژورنال: Journal of Biomedicine and Biotechnology
سال: 2010
ISSN: 1110-7243,1110-7251
DOI: 10.1155/2010/294582