منابع مشابه
Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease.
BACKGROUND The mechanisms involved in the initiation and maintenance of Crohn's disease are poorly understood. Previous studies have demonstrated an increased number of infiltrating CD4+ T cells within the inflammatory affected bowel wall in Crohn's disease. Novel therapy approaches using anti-CD4 antibodies are thought to be effective in Crohn's disease. AIMS Interleukin 16 (IL-16) has been ...
متن کاملCirculating interleukin-16 in systemic lupus erythematosus.
OBJECTIVE To investigate the relationship between interleukin (IL)-16 and systemic lupus erythematosus (SLE). METHODS Serum levels of IL-16 were examined in SLE patients using an enzyme-linked immunosorbent assay (ELISA). RESULTS The serum level of IL-16 in the patients was much higher than that in healthy volunteers (P < 0.001). An increase in IL-16 was observed in proportion to the activi...
متن کاملInterleukin 16 in Atherosclerosis and Cardiovascular Disease
Background and aim The development of clinical manifictations due to an eroded or ruptured atherosclerotic plaque, or occluded vessel, are one of the major causes of death world wide. It has been known for some time that atherosclerosis develops due to retention and modification of LDL particles in the vessel wall and the subsequent triggering of the immune system. The research presented within...
متن کاملNeuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.
Interleukin (IL)-16 is a proinflammatory cytokine that has attracted widespread attention because of its ability to block HIV replication. We describe the identification and characterization of a large neuronal IL-16 precursor, NIL-16. The N-terminal half of NIL-16 constitutes a novel PDZ domain protein sequence, whereas the C terminus is identical with splenocyte-derived mouse pro-IL-16. IL-16...
متن کاملImmunohistological expression of interleukin 16 in human tonsils.
BACKGROUND Interleukin 16 (IL-16) acts highly chemotactic on CD4-bearing cells. Besides chemotaxis, IL-16 has numerous immunomodulatory effects, and not only on T cells. OBJECTIVE To determine IL-16 expression in human tonsils. METHODS Tonsillar follicles were immunohistologically characterized to elicit a possible cellular source of IL-16 expression. RESULTS The mantle zone of immature a...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2000
ISSN: 0741-5400
DOI: 10.1002/jlb.67.6.757