Interleukin-1 in crescentic glomerulonephritis

Latent TGF- 1 Protects Against Crescentic Glomerulonephritis

Despite the critical role that TGFplays in renal fibrosis, transgenic mice that overexpress human latent TGF1 in the skin exhibit normal renal histology and function even though circulating levels of latent TGF1 are an order of magnitude higher than wild-type animals. In fact, latent TGF1 seems to protect against renal inflammation in a model of ureteral obstruction. It is unknown, however, whe...

T cells in crescentic glomerulonephritis.

Crescent formation in glomerulonephritis (GN) is a manifestation of severe glomerular injury that usually results in a poor clinical outcome. In humans, crescentic GN is frequently associated with evidence of either systemic or organ-specific autoimmunity. T cells play a major role in initiation of adaptive immune responses that lead to crescentic injury. In experimental models of crescentic GN...

Crescentic glomerulonephritis and centrocytic lymphoma.

New insight on crescentic glomerulonephritis

4þ haematuria, but urinary sediments showed few red blood cells (1-2-1/high-power fields). His renal function recovered concomitantly with improvement of haemolytic anaemia; thus, haemolysis might also have contributed to the development of his renal dysfunction. Indeed, haemolysisrelated renal dysfunction has occurred in patients with HCV infection [1]. Our patient showed cryoglobulinaemia, bu...

Osteopontin expression in human crescentic glomerulonephritis.

UNLABELLED Osteopontin expression in human crescentic glomerulonephritis. BACKGROUND Osteopontin is a molecule with diverse biological functions, including cell adhesion, migration, and signaling. The expression of osteopontin has been demonstrated in a number of models of renal injury in association with accumulations of monocyte/macrophages, including recent reports of osteopontin expressio...