Intergenerational concordance of brain structure between depressed mothers and their never-depressed daughters

Introduction Parents have significant genetic and environmental influences, which are known as intergenerational effects, on the cognition, behavior, brain of their offspring. These effects observed in patients with mood disorders, a particularly strong association depression between mothers daughters. Objectives The main purpose our study was to investigate female-specific transmission patterns human among never-depressed Methods We recruited 78 participants from 34 families, included remitted parents history biological used source-based surface-based morphometry analyses magnetic resonance imaging data examine degree associations structure four types parent-offspring dyads (i.e. mother-daughter, mother-son, father-daughter, father-son). Results Using independent component analysis, we found positive correlation gray matter exclusively mother-daughter within regions located default mode central executive networks, such bilateral anterior cingulate cortex, posterior precuneus, middle frontal gyrus, temporal superior parietal lobule, left angular gyrus. similar observations were not identified other three dyads. Conclusions current provides evidence for greater vulnerability daughters, but sons, developing whose depression. Our findings extend knowledge pathophysiology major psychiatric conditions that show sex biases may contribute development novel interventions targeting high-risk individuals. Disclosure Interest None Declared