Interfilament Spacing Is Preserved during Sarcomere Length Isometric Contractions in Rat Cardiac Trabeculae
نویسندگان
چکیده
منابع مشابه
Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing.
The increase in myofilament Ca(2+) responsiveness on an increase in sarcomere length (SL) is, in part, the cellular basis for Frank-Starling's law of the heart. It has been suggested that a decrease in myofilament lattice spacing (LS) in response to an increase in SL underlies this phenomenon. This hypothesis is supported by previous studies in which reduced muscle width induced by osmotic comp...
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Several recent reports have indicated that catecholamines may act directly on the crossbridge cycle, independent of intracellular calcium concentration changes. The present study investigated the effect of isoproterenol on peak force during twitches at constant sarcomere length and unloaded velocity of sarcomere shortening in isolated right ventricular trabeculae of hearts with V, or V3 isomyos...
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sarcomere shortening, by the "isovelocity release" technique. Contractile activation was varied by changing the calcium concentration in the bathing medium ([Ca2+J0). Slack SL was 1.85 ±0.04 ,m. When length of the muscle was held constant, the sarcomeres in the central region of the muscle shortened during the twitch by up to 21%. Both peak sarcomere isometric twitch force and unloaded velocity...
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Sarcomere length measurement by microscopic and laser diffraction techniques in trabeculae of rat heart, superfused with Krebs-Henseleit solution at 21 degrees C, showed spontaneous local sarcomere shortening after electrically stimulated twitches. The contractions originated in a region of several hundred micrometers throughout the width of the muscle close to the end of the preparation that w...
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The purpose of the present study was to describe sarcomere dynamics in thin trabeculae that were dissected from the right ventricle of kittens. The muscles were mounted in an experimental chamber and perfused with a modified Krebs-Henseleit solution (25 degrees C). Sarcomere length (SL) was measured by laser diffraction techniques; force, by a silicon strain gauge; and velocity of sarcomere sho...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2007
ISSN: 0006-3495
DOI: 10.1529/biophysj.107.104257