Interferons command Trim22 to fight against viruses

Engineering Viruses to Fight Cancer

With EMA approval in December 2015, and US FDA approval in October 2015 of an oncolytic herpesvirus for the treatment of nonresectable melanoma, we now have a novel class of anticancer agents to add to our ever-promising arsenal of cancer (immuno-) therapeutics. Talimogen laherparapvec (T-VEC) therapy involves direct, intratumoral injection of a herpes simplex type 1 (HSV-1) virus which has bee...

Effects of Interferons and Viruses on Metabolism

Interferons (IFNs) are potent pleiotropic cytokines that broadly alter cellular functions in response to viral and other infections. These alterations include changes in protein synthesis, proliferation, membrane composition, and the nutritional microenvironment. Recent evidence suggests that antiviral responses are supported by an IFN-induced rewiring of the cellular metabolism. In this review...

Fight against pneumonia.

Recently, WHO has decided to launch an annual “World Pneumonia Day” on November 2, 2009(1). The day will mobilize efforts to fight pneumonia, rightly called a ‘neglected’ or a ‘forgotten’ disease, that kills more than two million children under the age of five each year worldwide(2). The sudden shift of focus on pneumonia has raised many eyebrows and brought forward few issues that need clarifi...

The Fight against Poliomyelitis

The Fight against Poliomyelitis