Interferon-λs: the modulators of antivirus, antitumor, and immune responses
نویسندگان
چکیده
منابع مشابه
Interferon-λs: special immunomodulatory agents and potential therapeutic targets.
Interferon (IFN)-λs are a new addition to the old IFN family and share many similarities, such as antiviral and antiproliferative characteristics, with type I IFNs. IFN-λs also exhibit unique characteristics in immunomodulation. Accumulating studies have indicated the interactions between IFN-λs and immune cells, which lead to the regulation of the latter. IFN-λs can influence dendritic cells (...
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Interferon lambdas (IFNλs) are recently discovered cytokines acting not only at the first line of defense against viral infections but also at the mucosal barriers. In fact, a peculiar feature of the IFNλ system is the restricted expression of the functional IFNλR, which is known to be limited to epithelial cells and discrete leukocyte subsets, including the plasmacytoid dendritic cells (pDCs)....
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Allergic diseases have been closely related to Th2 immune responses, which are characterized by high levels of interleukin (IL) IL-4, IL-5, IL-9 and IL-13. These cytokines orchestrate the recruitment and activation of different effector cells, such as eosinophils and mast cells. These cells along with Th2 cytokines are key players on the development of chronic allergic inflammatory disorders, u...
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Classic studies over the last two decades have made virus-induced activation of the mammalian interferon-b (ifnb) gene a prototype of eukaryotic gene regulation [1–6]. Indeed, the compact ,50 base-pair enhancer region upstream of the ifnb transcription start site is amongst the beststudied stretches of mammalian DNA, and its function in regulation of ifnb expression is considered a paradigm of ...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2009
ISSN: 0741-5400
DOI: 10.1189/jlb.1208761