Interferon lambda 4 genotypes and resistance-associated variants in patients infected with hepatitis C virus genotypes 1 and 3
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چکیده
منابع مشابه
Interferon Resistance of Hepatitis C Virus Genotypes 1a/1b: Relationship to Structural E2 Gene Quasispecies Mutations
Hepatitis C virus (HCV) envelope glycoprotein-2 (E2) inhibits the interferon (IFN)–induced, double –stranded RNA activated protein kinase (PKR) via PKR eukaryotic initiation factor-2α phosphorylation homology domain (PePHD). Present study examined the genetic variability of the PePHD in patients receiving interferon therapy. The PePHD region from HCV genotype 1a/1b infected patients receiving I...
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متن کاملinterferon lambda 4 polymorphism predicts sustained viral response in hepatitis c virus patients irrespective of hepatitis c virus genotypes, ethnicity or treatment regimen: results from a meta-analysis
context there is growing evidence that interferon lambda 4 (ifnl4) polymorphism is related to sustained virological response (svr) in hepatitis c virus (hcv) infection. we analyzed the relationship between ifnl4 (rs368234815) polymorphism and svr in dual- and triple- therapy in hcv genotype 1, 2, 3 and 4 infected asian, caucasian and african patients. conclusions favorable ifnl4 rs368234815 gen...
متن کاملInterferon Lambda 4 Polymorphism Predicts Sustained Viral Response in Hepatitis C Virus Patients Irrespective of Hepatitis C Virus Genotypes, Ethnicity or Treatment Regimen: Results From a Meta-Analysis.
CONTEXT There is growing evidence that interferon lambda 4 (IFNL4) polymorphism is related to sustained virological response (SVR) in hepatitis C virus (HCV) infection. We analyzed the relationship between IFNL4 (rs368234815) polymorphism and SVR in dual- and triple- therapy in HCV genotype 1, 2, 3 and 4 infected Asian, Caucasian and African patients. EVIDENCE ACQUISITION We performed a syste...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2015
ISSN: 0270-9139
DOI: 10.1002/hep.28255