INTERFERON ASSAY AS A DIAGNOSTIC TEST

Utility of an interferon-gamma release assay as a potential diagnostic aid for active pulmonary tuberculosis.

INTRODUCTION Sensitivity, specificity, early confirmation and obtaining an optimal specimen are challenging problems in active tuberculosis (TB) diagnosis. Interferon-gamma release assay (IGRA) is a good indicator for latent TB but can it be useful as a diagnostic tool for active TB? This study was designed to address these challenges and assess the potential of IGRA as a diagnostic indicator o...

Diagnostic Utility of Interferon-γ Release Assay in Tuberculous Lymphadenitis

Two Case Reports of Netherton Syndrome: Hair Shaft Examination Is Known As a Diagnostic Test

Background: Netherton syndrome is a rare autosomal recessive disorder consisting of ichthyosiform dermatosis, hair shaft abnormalities and an atopic diathesis that presents as widespread erythematous skin. The aim of these reports is emphasis on the importance of the examination of hair as a diagnose route. Case presentation: Case 1: A 6 months old boy with respiratory distress and severe eryth...

Performance of Tuberculin Skin Test Measured against Interferon Gamma Release Assay as Reference Standard in Children

Objectives. International guidelines differ in the threshold of tuberculin skin test (TST) induration regarded as indicating Mycobacterium (M.) tuberculosis infection. Interferon gamma release assay (IGRA) results were used as reference to assess performance of TST induration thresholds for detection of M. tuberculosis infection in children. Design. Systematic review which included studies cont...

Fructosamine Assay As a Diagnostic Criterion In Thyroid Disorders

Background: Glycation is the process of non enzymatic addition or insertion of sugar to proteins, DNA and lipids. Fructosamine is the generic name for plasma proteins ketoamines; it refers to structure of ketoamine rearrangement product formed by interaction of fructose with ε-amino group of lysine residues of albumin. Its determination monitors the short term glycemic changes and may have a ro...