Interferon and PV stem cells

Interferon and PV stem cells.

In this issue of Blood, King et al demonstrate a novel mechanism of protection of hematopoietic stem cells by a gene that is negatively regulated by interferon signaling.3 This follows previous papers demonstrating that IFNstimulates normal hematopoietic stem cells from dormancy,4-6 which may eventually lead to depletion of the hematopoietic stem cell pool. Whether this differential effect is m...

Hematopoietic Stem Cells and Response to Interferon

Stem Cells So far! Stem Cell Therapy Facts and Principles

Stem cells are cells with the ability to divide for indefinite periods and to give rise to specialized cells.  Stem cell therapy has now been emerged as an extraordinary promise to treat a wide range of diseases and conditions.  However, except blood stem cell transfer by bone marrow transplant which has been used as an standard practice for more than 50 years, nearly all of therapeutic potenti...

Jak2V617F myeloproliferative neoplasm stem cells and interferon-alpha

The myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoiesis that arise as a result of aberrant activation of tyrosine kinases and result in the proliferation and accumulation of mature myeloid cells in the blood, bone marrow and spleen. The prototypical MPN, chronic myeloid leukemia (CML) is caused by constitutive activation of ABL kinase occurring as a result of the BCR-ABL f...

Comparing the Expression Levels of Alkaline Phosphatase, Gfra1, Lin28, and Sall4 Genes in Embryonic Stem Cells, Spermatogonial Stem Cells, and Embryonic Stem-Like Cells in Mice

Background and purpose: Spermatogenesis is a well-organized process that is influenced by a variety of factors. Alkaline phosphatase, and Gfra1, Lin28, and Sall4 genes are among the key players in this interconnected process. This study aimed to investigate the expression levels of Gfra1, Lin28, and Sall4 genes in embryonic, spermatogonial, and embryonic stem-like (ES-like) cells in mice. Mate...