منابع مشابه
Adjuvant interferon for melanoma.
In their recent review, Punt and Eggermont [1] state that “combined data from low-dose IFN-α [interferon-α] trials does not suggest a benefit in ... DFS [disease-free survival]”. This conclusion is inconsistent with the results of a metaanalysis of these trials [2]. It is surprising that Punt and Eggermont [1] do not mention this study, especially as the latter was an author on the meta-analysi...
متن کاملHigh-risk surgically resected pediatric melanoma and adjuvant interferon therapy.
BACKGROUND Pediatric patients with high-risk surgically resected melanoma are at risk for relapse, yet little is known about these young patients and how they tolerate high-dose interferon therapy. PROCEDURE We reviewed medical records of patients (< or =18 years) with high-risk melanoma referred to the University of Michigan Pediatric Hematology-Oncology service between January 1989 and July...
متن کاملUpdate on adjuvant interferon therapy for high-risk melanoma.
Melanoma is almost 100% curable when diagnosed early, but when metastatic to distant organs, it is associated with a poor survival. The interferons have shown the mostpromise in the treatment of melanoma and interferon-alpha has been the most extensively studied. In recent trials, interferon alfa-2b (Intron A) administered at maximally tolerated doses for 1 year produced improvements in both re...
متن کاملAdjuvant interferon alfa for melanoma.
The author poses the question “Why did these study results not lead to a global consensus about interferon treatment as standard of care?” The answer is quite simple: The E1684 adjuvant high-dose interferon (hdifn) trial, while initially positive, was later shown to be negative. Remarkably, in spite of a p value of 0.09, the principal investigator still interpreted the trial as positive 1. Canc...
متن کاملAdjuvant therapy of melanoma.
In 2001, the American Joint Committee on Cancer Melanoma Staging Committee proposed and created a new staging system for melanoma. This new system will become official in 2002, with the publication of the sixth edition of the AJCC Cancer Staging Manual. The new system identifies significant prognostic variables in patients with melanoma and validates them in an analysis of 17,600 patients, maki...
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ژورنال
عنوان ژورنال: Cancer
سال: 1996
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(19960901)78:5<944::aid-cncr2>3.0.co;2-c