Interactive Regulation between Aliphatic Hydroxylation and Aromatic Hydroxylation of Thaxtomin D in TxtC: A Theoretical Investigation
نویسندگان
چکیده
منابع مشابه
Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation.
Studies in this laboratory on the conversion of tyramine to hydroxytyramine by homogenates of adrenal medulla showed that hydroxylation occurred maximally on the addition of ascorbic acid. Further investigation revealed that the hydroxylation did not require adrenal tissue, but could occur in the presence of ascorbic acid and oxygen. This observation led to a study of the r61e of ascorbic acid ...
متن کاملRegioselectivity of aliphatic versus aromatic hydroxylation by a nonheme iron(II)-superoxo complex.
Many enzymes in nature utilize molecular oxygen on an iron center for the catalysis of substrate hydroxylation. In recent years, great progress has been made in understanding the function and properties of iron(IV)-oxo complexes; however, little is known about the reactivity of iron(II)-superoxo intermediates in substrate activation. It has been proposed recently that iron(II)-superoxo intermed...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.
The alpha-ketoglutarate-dependent hydroxylases and halogenases employ similar reaction mechanisms involving hydrogen-abstracting Fe(IV)-oxo (ferryl) intermediates. In the halogenases, the carboxylate residue from the His(2)(Asp/Glu)(1) "facial triad" of iron ligands found in the hydroxylases is replaced by alanine, and a halide ion (X(-)) coordinates at the vacated site. Halogenation is thought...
متن کاملCombined experimental and theoretical study on aromatic hydroxylation by mononuclear nonheme iron(IV)-oxo complexes.
The hydroxylation of aromatic compounds by mononuclear nonheme iron(IV)-oxo complexes, [FeIV(Bn-tpen)(O)]2+ (Bn-tpen=N-benzyl-N,N',N'-tris(2-pyridylmethyl)ethane-1,2-diamine) and [FeIV(N4Py)(O)]2+ (N4Py=N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine), has been investigated by a combined experimental and theoretical approach. In the experimental work, we have performed kinetic studies of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Inorganic Chemistry
سال: 2021
ISSN: 0020-1669,1520-510X
DOI: 10.1021/acs.inorgchem.1c00154