Interactions in dopamine and indole loaded thermosensitive hydrogels seen by high sensitivity microDSC. Implications for drug delivery

Abstract Controlled and targeted drug delivery systems consist of a carrier matrix one or more active ingredients. One the roles is to regulate release drug. Uptake, release, differential scanning microcalorimetry (DSC) powder X-ray diffraction (XRD) techniques were used reveal interactions governing dopamine indole from thermoresponsive model polymer gel. The can be completely recovered loaded matrix. self-assembling affinity molecules reduces their interaction with polymer, water form uniform protecting sheath. Thus neither kinetics nor temperature phase transition are influenced by dopamine. DSC results imply formation dopamine-rich domains above transition. Indole, on other hand, readily substitutes for through between C=O sites NH groups loss hydrophobic decelerated fluctuation decorated chains result in much slower depleted temperature. distribution after drying found amorphous form. Dopamine, contrary, forms crystalline regions.