Interactions between CYP7A1 A-204C and ABCG8 C1199A polymorphisms on lipid lowering with atorvastatin
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منابع مشابه
Carvedilol: A Promising Drug Combined with Lipid-lowering Medications for Patients with Hypertension and Heart Failure
Background: Statins frequently cause myopathy especially in combination with fibrates, and physical activity is considered a trigger for the muscle disorder. Elevated plasma levels of creatine kinase (CK), lactate dehydrogenase (LDH) and aldolase, are the main indicators of the severity of myopathy. Carvedilol is commonly used with lipid-lowering drugs in the management of heart failure, hypert...
متن کاملFormulation and Evaluation of Nanocrystals of a Lipid Lowering Agent
Atorvastatin calcium, the lipid lowering agent, is taken as a model drug characterized by poor water solubility and bioavailability. In this study an attempt was made for preparation of nanocrystals using high pressure homogenization. A number of stabilizers were included as well as polymers at different concentrations, and the formulations were homogenized for ten cycles at a pressure of 1000 ...
متن کاملComparative evaluation between chitosan and atorvastatin on serum lipid profile changes in hyperlipidemic cats
The purpose of the present survey was to determine the effects of the chitosan and atorvastatin on serum lipid profile changes and the influence of time on treatment process in cats. For the management of cholesterol induced hyperlipidemia, twenty-one healthy cats were randomly divided into three equal groups. Group A (control) included seven cats that were fed with cholesterol powder (4 g/kg f...
متن کاملFormulation and Evaluation of Nanocrystals of a Lipid Lowering Agent
Atorvastatin calcium, the lipid lowering agent, is taken as a model drug characterized by poor water solubility and bioavailability. In this study an attempt was made for preparation of nanocrystals using high pressure homogenization. A number of stabilizers were included as well as polymers at different concentrations, and the formulations were homogenized for ten cycles at a pressure of 1000 ...
متن کاملAssociation of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects
BACKGROUND Statins are effective agents in the primary and secondary prevention of cardiovascular disease, but treatment response to statins varies among individuals. We analyzed multiple genetic polymorphisms and assessed pharmacokinetic and lipid-lowering responses after atorvastatin 80 mg treatment in healthy Korean individuals. METHODS Atorvastatin 80 mg was given to 50 healthy Korean mal...
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ژورنال
عنوان ژورنال: Journal of Clinical Pharmacy and Therapeutics
سال: 2010
ISSN: 0269-4727
DOI: 10.1111/j.1365-2710.2010.01227.x