Interaction between phenytoin and antacids.

Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam

A 3-year-old female patient developed chorea possibly due to an interaction between phenytoin, phenobarbital and clobazam used for generalized tonic clonic seizures. Phenytoin withdrawal resulted in recovery within 24 hours. Post reaction computerized tomography (CT)-scan of brain was normal. Combined use of anti-seizure drugs and interactions between them may be responsible for the reaction. T...

Fatal phenytoin warfarin interaction.

Digoxin-phenytoin interaction.

Tolerance of Rifampicin SIR,-One of the virtues of rifampicin is said to be a good patient tolerance which, as you have noted (30 August, 1969, p. 487), should be particularly valuable in treatment of tuberculosis where tolerance is poor. To demonstrate objectively whether this good tolerance extends to domiciliary ambulant therapy we have used a simple urine test for rifampicin on patients att...

Antipeptic activity of antacids.

An in vitro experiment based on the digestion of haemoglobin with pepsin was carried out to test the claim made by some manufacturers that the antacids used in their proprietary preparations had an intrinsic antipeptic activity independent of the change brought about by alteration of pH. In no case could these claims be substantiated.

Pharmacokinetic Interaction Study between Lansoprazole with Phenytoin or Ciprofloxacin in Healthy Volunteers

The pharmacokinetic interaction between lansoprazole with phenytoin and ciprofloxacin in healthy male volunteers was evaluated. In two separate experiments, a single dose of 30 mg lansoprazole was administered alone or in combination with phenytoin or ciprofloxacin to 11, respectively 18 healthy volunteers in two stages treatment of study design, separated by a period in which the phenytoin or ...