منابع مشابه
Targeted Therapy in Ewing Sarcoma
Despite marked improvement in the prognosis of patients with nonmetastatic Ewing sarcoma (ES), the outcome for patients with recurrent or metastatic disease remains poor. Insight into key biologic processes in ES could provide new therapeutic targets. The particular biologic feature of ES, the fusion of the EWS gene with a member of the ETS family of genes, is present in >95% of cases. The EWS-...
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Ewing sarcoma is an aggressive, poorly differentiated neoplasm of solid bone that disproportionally afflicts the young. Despite intensive multi-modal therapy and valiant efforts, 70% of patients with relapsed and metastatic Ewing sarcoma will succumb to their disease. The persistent failure to improve overall survival for this subset of patients highlights the urgent need for rapid translation ...
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MicroRNAs (miRs) have emerged recently as important regulators of gene expression in the cell. Frequently dysregulated in cancer, miRs have shed new light on molecular mechanisms of oncogenesis, and have generated substantial interest as biomarkers, and novel therapeutic agents and targets. Recently, a number of studies have examined miR biology in Ewing sarcoma. Findings indicate that alterati...
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Histologic evaluation of neoadjuvant chemotherapy effect is a well-established prognostic indicator in osteosarcoma and Ewing sarcoma arising in bone. Although tumor necrosis is a primary histologic response for the treatment, secondary degenerative changes following necrosis are frequently shown in those tumors. We reviewed some cases of Ewing sarcoma and osteosarcoma of bone with variable his...
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The insulin-like growth factor (IGF) signal transduction pathway appears to play a key role in the development and proliferation of the Ewing sarcoma family of tumors. Integration of anti-IGF-1 receptor therapy into the standard treatment for these patients is a novel approach that will likely be incorporated into future treatment to determine whether such agents will improve the outcome for pa...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2012
ISSN: 1759-4774,1759-4782
DOI: 10.1038/nrclinonc.2012.200