Integron Involvement in Environmental Spread of Antibiotic Resistance
نویسندگان
چکیده
منابع مشابه
Integron Involvement in Environmental Spread of Antibiotic Resistance
The spread of antibiotic-resistant bacteria is a growing problem and a public health issue. In recent decades, various genetic mechanisms involved in the spread of resistance genes among bacteria have been identified. Integrons - genetic elements that acquire, exchange, and express genes embedded within gene cassettes (GC) - are one of these mechanisms. Integrons are widely distributed, especia...
متن کاملEnvironmental factors influencing the development and spread of antibiotic resistance
Antibiotic resistance and its wider implications present us with a growing healthcare crisis. Recent research points to the environment as an important component for the transmission of resistant bacteria and in the emergence of resistant pathogens. However, a deeper understanding of the evolutionary and ecological processes that lead to clinical appearance of resistance genes is still lacking,...
متن کاملModeling the Spread of Antibiotic Resistance
This paper describes a stochastic implementation of Austin et al.’s (1999) model of the spread of antibiotic resistance in a population of fixed size under varying conditions of antibiotic use. The population is divided into sub-groups: individuals colonized by commensal bacteria and an uncolonized group. The colonized group is further divided according to whether the commensal bacteria are sen...
متن کاملIntegron attI1 Sites, Not Riboswitches, Associate with Antibiotic Resistance Genes
In a recent publication in Cell (Jia et al., 2013), the authors conclude from bioinformatics, genetic, and biochemical analyses that a conserved sequence element associated with antibiotic resistance genes represents a novel widespread riboswitch class for certain aminoglycosides. Below, we point out previously reported functions for this element that were not discussed by the authors, and we n...
متن کاملAntibiotic Resistance: Origins, Evolution, Selection and Spread
Antibiotic resistance thwarts the treatment of infectious diseases worldwide. Although a number of factors can be identified which contribute to the problem, clearly the antibiotic as a selective agent and the resistance gene as the vehicle of resistance are the two most important, making up a 'drug resistance equation'. Both are needed in order for a clinical problem to arise. Given sufficient...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2012
ISSN: 1664-302X
DOI: 10.3389/fmicb.2012.00119