Integrins as Therapeutic Targets: Successes and Cancers
نویسندگان
چکیده
منابع مشابه
Integrins as Therapeutic Targets: Successes and Cancers
Integrins are transmembrane receptors that are central to the biology of many human pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with an emerging role as local activators of TGFβ, they influence cancer, fibrosis, thrombosis and inflammation. Their ligand binding and some regulatory sites are extracellular and sensitive to pharmacological interventi...
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ژورنال
عنوان ژورنال: Cancers
سال: 2017
ISSN: 2072-6694
DOI: 10.3390/cancers9090110