Integrator enhances enhancers

UCSC Data Integrator and Variant Annotation Integrator

UNLABELLED Two new tools on the UCSC Genome Browser web site provide improved ways of combining information from multiple datasets, optionally including the user's own custom track data and/or data from track hubs. The Data Integrator combines columns from multiple data tracks, showing all items from the first track along with overlapping items from the other tracks. The Variant Annotation Inte...

Double Integrator

In real-world applications, controllers must operate in the presence of an untold number of off-nominal conditions that either were not or could not be accounted for during formal synthesis. Engineers compensate for these real-world effects by extensive simulation and testing. Only after extensive evaluation and validation can a controller be accepted for critical applications. In addition, it ...

Outsourcing and competence hollowing - out : Systems integrator vs . knowledge integrator ?

The paper analyses the organization of the new product development process at FIAT from a resource-based perspective. The focus is on organizational resources for integrating dispersed specialist knowledge required in the development of complex products. The analysis shows how applying a resource-based perspective is able to uncover negative long-term effects of outsourcing on the competence ba...

Genetic enhancers.

A genetic enhancer is a mutation in one gene that intensifies the phenotype caused by a mutation in another gene. The phenotype of the double mutant is much stronger than the summation of the single mutant phenotypes. The isolation of enhancers can lead to the identification of interacting genes, including genes that act redundantly with respect to each other. Examples in Caenorhabditis elegans...

The Electronic Numerical Integrator