Integrating efficacy and safety of vedolizumab compared with other advanced therapies to assess net clinical benefit of ulcerative colitis treatments: a network meta-analysis
نویسندگان
چکیده
Objectives: Because only one head-to-head randomized trial of biologics for moderate-to-severe UC has been performed, indirect treatment comparisons remain important. This systematic review and net...
منابع مشابه
a comparison of teachers and supervisors, with respect to teacher efficacy and reflection
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15 صفحه اولClinical efficacy of local injection therapies for lateral epicondylitis: A systematic review and network meta-analysis
Background: We aimed to compare the efficacy of local injection therapies for lateral epicondylitis in a Bayesian framework. Methods: We searched the Embase, PubMed, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and ProQuest, for randomized controlled trials published from inception to February 2021 in any languages. The injection therapies included corticosteroids (C...
متن کاملEfficacy and safety of selumetinib compared with current therapies for advanced cancer: a meta-analysis.
BACKGROUND AND AIM Selumetinib is a promising and interesting targeted therapy agent as it may reverse radioiodine uptake in patients with radioiodine-refractory differentiated thyroid cancer. We conduct this meta- analysis to compare the efficacy and safety of selumetinib with current therapies in patients with advanced cancer. METHODS An electronic search was conducted using PubMed/ Medicin...
متن کاملThe safety of vedolizumab for ulcerative colitis and Crohn's disease
OBJECTIVE Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab. DESIGN Safety data (May 2009-June 2013) from six trials of vedolizumab were integrated. Adverse events were evaluated in patients who received ≥1 dose of vedolizumab or placebo and were reported ...
متن کاملEfficacy and Safety of Vedolizumab in Ulcerative Colitis and Crohn’s Disease Patients Stratified by Age
INTRODUCTION The efficacy and safety of vedolizumab, a gut-selective α4β7 integrin antibody, were demonstrated in the GEMINI 1 and GEMINI 2 clinical trials of adults aged 18-80 years. We investigated the efficacy and safety of vedolizumab in patients stratified by age from the GEMINI trials. METHODS Safety and efficacy, including clinical response, clinical remission, and corticosteroid-free ...
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ژورنال
عنوان ژورنال: Expert Review of Gastroenterology & Hepatology
سال: 2021
ISSN: ['1747-4132', '1747-4124']
DOI: https://doi.org/10.1080/17474124.2021.1880319