Insulin Signaling in Bupivacaine-induced Cardiac Toxicity
نویسندگان
چکیده
منابع مشابه
The Possible Mechanisms Underlying Epinephrine Worsens Bupivacaine Induced Cardiac Toxicity
experimental animals. But which occurs first and is more important? Put another way, do patients with bupivacaine toxicity die of arrhythmias, contractile failure, or a combination of the two? Epinephrine is a first-line agent for treating cardiac arrest; but why patients who have undergone bupivacaine induced cardiac arrest are often resistant to adrenergic therapy? This article reviews the me...
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Bupivacaine is widely used as a local anesthetic. Central nervous system (CNS) and cardiovascular toxicity are well known side effects. However, there has been no report of bupivacaine-induced myocardial injury. We present a case of bupivacaine cardiac toxicity mimicking an acute non-ST segment elevation myocardial infarction, which was eventually diagnosed as bupivacaine-induced cardiac toxici...
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BACKGROUND Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractory to conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-induced cardiovascular collapse in pentobarbital-anesthetized rabbits. METHODS Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolus o...
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TNFa has been shown to be an important mediator of insulin resistance linked to obesity. This cytokine induces insulin resistance, at least in part, through inhibition of the tyrosine kinase activity of the insulin receptor. Recently, a new class of compounds, the antidiabetic thiazolidinediones (TZDs), has been shown to improve insulin resistance in obesity and non-insulin-dependent diabetes m...
متن کاملInsulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
Bupivacaine inhibits cardiac conduction and contractility. Insulin enhances cardiac repolarization and myocardial contractility. We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia. Cardiovascular collapse (CVC) was induced ...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2016
ISSN: 0003-3022
DOI: 10.1097/aln.0000000000000974