Insulin sensitizer prevents and ameliorates experimental type 1 diabetes
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چکیده
منابع مشابه
Adenosine receptor activation ameliorates type 1 diabetes.
Growing evidence indicates that adenosine receptors could be promising therapeutic targets in autoimmune diseases. Here we studied the role of adenosine receptors in controlling the course of type 1 diabetes. Diabetes in CD-1 mice was induced by multiple-low-dose-streptozotocin (MLDS) treatment and in nonobese diabetic (NOD) mice by cyclophosphamide injection. The nonselective adenosine recepto...
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Insulin treatment Basal insulin. Malcolm Nattrass (Birmingham, U.K.) discussed basal insulin analogs, noting that the ideal approach will lead to “a flat profile that is reproducible.” The development of basal insulin began with protamine zinc insulin in 1936, followed by NPH insulin in 1946 and zinc insulins lente, semilente, and ultralente in 1951. All of these preparations have high variabil...
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Type 1 diabetes mellitus (T1DM) results from a specific autoimmune mediated destruction of the pancreatic beta-cells. PDX-1 induced developmentally redirected liver cells were suggested to restore the ablated pancreatic function in chemically induced diabetes. However, developmentally redirected liver cells, may have acquired along with the desired beta-cell characteristics and functions, also ...
متن کاملPterocarpus santalinus ameliorates streptozotocin-induced diabetes mellitus via anti-inflammatory pathways and enhancement of insulin function
Objective(s): Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on streptozotocin (STZ)-induced DM as compared to glus...
متن کاملType 1 Diabetes: Clinical and Experimental
Type 1 diabetes should be perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing cells in the pancreatic islets in genetically susceptible individuals. The past 12 months have provided new insights both into the pathogenesis and treatment of this disease. Further evidence has been provided that insulin may be the c...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2017
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00329.2016