Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?
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منابع مشابه
Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse?
Insulin resistance, recently recognized as a strong predictor of disease in adults, has become the leading element of the metabolic syndrome and renewed as a focus of research. The condition exists when insulin levels are higher than expected relative to the level of glucose. Thus, insulin resistance is by definition tethered to hyperinsulinemia. The rising prevalence of medical conditions wher...
متن کاملInsulin Resistance and Hyperinsulinemia
OBJECTIVE Recently, it has been suggested that insulin resistance and hyperinsulinemia can exist in isolation and have differential impacts on cardiovascular disease (CVD). To evaluate this suggestion, we assessed the degree of discordance between insulin sensitivity and insulin response in a healthy, nondiabetic population. RESEARCH DESIGN AND METHODS Insulin sensitivity was quantified by de...
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Macroand microvascular complications are both main causes of morbidity and mortality in type 1 and type 2 diabetes, but macrovascular complications have an increased incidence even before the onset of type 2 diabetes. While high blood glucose and glucose-induced protein and lipid modifications—the advanced glycation endproducts—can be triggers of both macroand microvascular disease once diabete...
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Recent work to elucidate the cause of obesity-associated hypertension has focused on insulin resistance and hyperinsulinemia. A significant amount of epidemiologic and correlational evidence suggests a link between these factors and obesity-associated hypertension, and acute insulin infusion studies have revealed renal, neural, and cardiovascular effects of this hormone that, if maintained chro...
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Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas inactivation of Irs2 does. Previously, we have shown that endothelial ablation of...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2008
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc08-s264