منابع مشابه
Novel concepts in insulin regulation of hepatic gluconeogenesis.
The regulation of hepatic gluconeogenesis is an important process in the adjustment of the blood glucose level, and pathological changes in the glucose production of the liver are a central characteristic in type 2 diabetes. The pharmacological intervention in signaling events that regulate the expression of the key gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK) and the catalyt...
متن کاملChronic and transitional regulation of gluconeogenesis and glyconeogenesis by insulin and glucagon in neonatal calf hepatocytes.
Milk-fed calves were used as a source of hepatocytes to establish monlayers to test the effects of chronic (41 h) incubation with no hormone, 100 nM insulin, or 100 nM glucagon on gluconeogenesis (glucose retained as glycogen plus glucose released into the medium) from 2.5 mM [2-(14)C]propionate and 2.0 mM [U-14C]lactate (1.0 mM lactate plus 1.0 mM pyruvate) during a subsequent 3-h (acute) incu...
متن کاملThe regulation of gluconeogenesis by diet and insulin in rainbow trout (Salmo gairdneri).
1. The effects of diet composition and insulin treatment on blood glucose level, blood amino acid concentrations, the activities of two hepatic gluconeogenic enzymes (fructose diphosphatase, EC 3.1 .3.11; phosphoenolpyruvate carboxykinase, EC 4 .1 . 1 .32) and of two hepatic glycolytic enzymes (hexokinase, EC 2 .7 .1 . 1 ; pyruvate kinase, EC 2 . 7 . 1 .40) were examined in rainbow trout (Sulmo...
متن کاملInsulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis.
The role of a glucagon/cAMP-dependent protein kinase-inducible coactivator PGC-1α signaling pathway is well characterized in hepatic gluconeogenesis. However, an opposing protein kinase B (PKB)/Akt-inducible corepressor signaling pathway is unknown. A previous report has demonstrated that small heterodimer partner-interacting leucine zipper protein (SMILE) regulates the nuclear receptors and tr...
متن کاملRegulation of gluconeogenesis and lipogenesis. The regulation of mitochondrial pyruvate metabolism in guinea-pig liver synthesizing precursors for gluconeogenesis.
1. The carboxylation of pyruvate to oxaloacetate by pyruvate carboxylase in guinea-pig liver mitochondria was determined by measuring the amount of (14)C from H(14)CO(3) (-) fixed into organic acids in the presence of pyruvate, ATP, Mg(2+) and P(i). The main products of pyruvate carboxylation were malate, fumarate and citrate. Pyruvate utilization, metabolite formation and incorporation of (14)...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2017
ISSN: 0077-8923
DOI: 10.1111/nyas.13435