Insulin induces expression of the hepatic <i>vaspin</i> gene
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چکیده
منابع مشابه
Hypothalamic resistin induces hepatic insulin resistance.
Circulating resistin stimulates endogenous glucose production (GP). Here, we report that bi-directional changes in hypothalamic resistin action have dramatic effects on GP and proinflammatory cytokine expression in the liver. The infusion of either resistin or an active cysteine mutant in the third cerebral ventricle (icv) or in the mediobasal hypothalamus stimulated GP independent of changes i...
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Insulin regulates the expression of more than 150 genes, indicating that this is a major action of this hormone. At least eight distinct consensus insulin response sequence (IRSs) have been defined through which insulin can regulate gene transcription. These include the serum response element, the activator protein 1 ('AP-1') motif, the Ets motif, the E-box motif and the thyroid transcription f...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2020
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.ej19-0276