Insulin Independence After Islet Transplantation Into Type I Diabetic Patient
نویسندگان
چکیده
منابع مشابه
Insulin independence after islet transplantation into type I diabetic patient.
Effective clinical trials of islet transplantation have been limited by the inability to transplant enough viable human islets into patients with type I (insulin-dependent) diabetes mellitus to eliminate their exogenous insulin requirement. We report the first type I diabetic patient with an established kidney transplant on basal cyclosporin immunosuppression who was able to eliminate the insul...
متن کاملIntrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence.
Islet allotransplantation can provide prolonged insulin independence in selected individuals with type 1 diabetes. Whether islet transplantation also restores hypoglycemic counterregulation is unclear. To determine if hypoglycemic counterregulation is restored by islet transplantation, we studied hormone responses and hypoglycemic symptom recognition in seven insulin-independent islet transplan...
متن کاملPotent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes.
The seemingly inexorable decline in insulin independence after islet transplant alone (ITA) has raised concern about its clinical utility. We hypothesized that induction immunosuppression therapy determines durability of insulin independence. We analyzed the proportion of insulin-independent patients following final islet infusion in four groups of ITA recipients according to induction immunoth...
متن کاملIslet Transplantation in Type I Diabetes Mellitus
For most patients with type I diabetes, insulin therapy and glucose monitoring are sufficient to maintain glycemic control. However, hypoglycemia is a potentially lethal side effect of insulin treatment in patients who are glycemically labile or have hypoglycemia-associated autonomic failure [1]. For those patients, an alternative therapy is beta cell replacement via pancreas or islet transplan...
متن کاملEighty years after insulin: parallels with modern islet transplantation.
© 2002 Canadian Medical Association or its licensors T his year marks the 80th anniversary of the publication in CMAJ of the discovery of insulin by Frederick Banting and his colleagues at the University of Toronto. Some interesting historical parallels have emerged with the success of islet replacement therapy in diabetes. Up until just a few weeks ago, human islet cells were being prepared in...
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ژورنال
عنوان ژورنال: Diabetes
سال: 1990
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diab.39.4.515