منابع مشابه
Insulin breaks hearts
Time keepers abound very cell in the body has its own little clock, according to Emi Nagoshi, Ueli Schibler (University of Geneva, Switzerland), and colleagues. These peripheral clocks may be closely related to the body’s central clock—the suprachiasmatic nucleus (SCN). Neurons of the SCN maintain circadian gene expression for long periods of time. Other cells, however, were thought to rely on ...
متن کاملWhen it breaks , it breaks
Dependencies among software projects and libraries are an indicator of the often implicit collaboration among many developers in software ecosystems. Negotiating change can be tricky: changes to one module may cause ripple effects to many other modules that depend on it, yet insisting on only backwardcompatible changes may incur significant opportunity cost and stifle change. We argue that awar...
متن کاملInsulin Inhibits Cardiac Contractility by Inducing a Gi-Biased b2-Adrenergic Signaling in Hearts
Insulin and adrenergic stimulation are two divergent regulatory systems that may interact under certain pathophysiological circumstances. Here, we characterized a complex consisting of insulin receptor (IR) and b2adrenergic receptor (b2AR) in the heart. The IR/b2AR complex undergoes dynamic dissociation under diverse conditions such as Langendorff perfusions of hearts with insulin or after eugl...
متن کاملParallel Stimulation of Glucose and Mg Accumulation by Insulin in Rat Hearts and Cardiac Ventricular Myocytes
The stimulation of b-adrenoceptors in cardiac cells results in a rapid loss of cellular Mg. Because insulin physiologically counteracts several of the cellular effects mediated by the activation of b-adrenoceptors and the elevation of cytosolic cAMP levels, we investigated whether insulin administration could prevent Mg mobilization from rat hearts and ventricular myocytes. Rat hearts were perf...
متن کاملInsulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27.
Six hours after insulin treatment, hearts express heat shock protein 70 (Hsp70) and have improved contractile function after ischemia-reperfusion injury. In this study we examined hearts 1 h after insulin treatment for contractile function and for expression of Hsp70 and Hsp27. Adult, male Sprague-Dawley rats were assigned to groups: 1) sham, 2) control, 3) insulin injected (200 microU/g body w...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1676rr3