Insulin- and Contraction-Induced Glucose Transporter 4 Traffic in Muscle
نویسندگان
چکیده
منابع مشابه
The effects of muscle contraction and insulin on glucose-transporter translocation in rat skeletal muscle.
The effect of electrically induced muscle contraction, insulin (10 m-units/ml) and electrically-induced muscle contraction in the presence of insulin on insulin-regulatable glucose-transporter (GLUT-4) protein distribution was studied in female Sprague-Dawley rats during hindlimb perfusion. Plasma-membrane cytochalasin B binding increased approximately 2-fold, whereas GLUT-4 protein concentrati...
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Introduction: Diabetes mellitus (DM) is now seen as a worldwide epidemic disease with high prevalence. Exercise training (ET) is known to promote beneficial changes in diabetic patients. The aim of this study was to compare the impact of continuous and intermittent aerobic training on glucose-4 transporter protein (GLUT-4) levels and insulin sensitivity in diabetic rats. Materials and meth...
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OBJECTIVE TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the function of TBC1D1 in muscle is not known. Genetic linkage analyses show a TBC1D1 R125W missense variant confers risk for severe obesity in humans. The objective of this study wa...
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Inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. So the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and ipratropium against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig. ...
متن کاملRegulates Glucose Transport in Skeletal Muscle TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle Running Head: TBC1D1 Regulates Glucose Transport in Skeletal Muscle
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online...
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ژورنال
عنوان ژورنال: Exercise and Sport Sciences Reviews
سال: 2013
ISSN: 0091-6331
DOI: 10.1097/jes.0b013e318275574c