Insulin 3-like hormone and its role in epididymo-testicular descent

Insulin 3-like hormone and its role in epididymo-testicular descent.

PURPOSE The role of insulin 3-like (Insl3) hormone signaling in the testicular descent process has been demonstrated. The purpose of the present study was to evaluate epididymal development in Insl3-deficient mice. MATERIALS AND METHODS Heterozygous and homozygous Insl3 mutants of a mixed CD1 X 129/Sv genetic background were generated by breeding Insl3-/- females with Insl3+/- males, and thei...

INSL3 (INSULIN-LIKE PEPTIDE 3) An Insulin-like Circulating Hormone

On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility

This comprehensive review provides in-depth coverage of progress made in understanding the molecular mechanisms underlying cryptorchidism, a frequent pathology first described in about 1786 by John Hunter. The first part focuses on the physiology, embryology, and histology of epididymo-testicular descent. In the last 20 years epididymo-testicular descent has become the victim of schematic drawi...

Testicular Descent.

1Department of Urology, University General Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece; 2First Pediatric Surgery Clinic, Aghia Sophia Children’s Hospital, Athens, Greece; 3Department of Urology, Tottori University School of Medicine, Yonago, Japan; 4Laboratory of Molecular Urology and Genetics of Human Reproduction, Department of Urology, Ioannina Univers...

Effect of Six Months of Aerobic Exercise on Serum Levels of Insulin, Growth Hormone and Insulin-Like Growth Hormone 1 in Sedentary Obese Women

ABSTRACT            Background and Objectives: Inactivity, obesity and hormone disorders can lead to various diseases in obese and non-athletic individuals. The objective of this study was to investigate effects of six months of aerobic exercise on serum levels of insulin, growth hormone (GH) and insulin-like growth hormone 1 (IGF-1) in sedent...