Instrumental Error under Mechanical Vibration III

Vibration, Mechanical Shock, and Impact

Time-varying forces and accelerations occur in daily life, and are commonly experienced, for example, in an elevator and in aircraft, railway trains, and automobiles. All of these situations involve motion of the whole body transmitted through a seat, or from the floor in the case of a standing person, where the human response is commonly related to the relative motion of body parts, organs, an...

Diagnosis Measurement Error and Instrumental Variables

As is well understood among clinical researchers, medical diagnoses often suffer from substantial measurement error. This is particularly true for mental health diagnoses.1 Reliance on inaccurate diagnosis indicators can substantially compromise researchers’ and clinicians’ ability to reliably evaluate treatment approaches, measure clinical progress, or estimate relationships between patient at...

Part III: Causality 17 Instrumental Sets

Calcium Signaling in Live Cells on Elastic Gels under Mechanical Vibration at Subcellular Levels

A new device was designed to generate a localized mechanical vibration of flexible gels where human umbilical vein endothelial cells (HUVECs) were cultured to mechanically stimulate these cells at subcellular locations. A Fluorescence Resonance Energy Transfer (FRET)-based calcium biosensor (an improved Cameleon) was used to monitor the spatiotemporal distribution of intracellular calcium conce...

Mechanical Bed for Investigating Sleep-Inducing Vibration

In running cars or trains, passengers often feel sleepy. Our study focuses on this physiological phenomenon. If a machine can reproduce this phenomenon, it is feasible to put a person, such as an insomnia patient or an infant, to sleep without any harmful effects. The results of our previous study suggest that low-frequency vibration induces sleep. This report describes a new mechanical bed for...