Insights into DDT Resistance from the Drosophila melanogaster Genetic Reference Panel
نویسندگان
چکیده
منابع مشابه
Insights into DDT Resistance from the Drosophila melanogaster Genetic Reference Panel
Insecticide resistance is considered a classic model of microevolution, where a strong selective agent is applied to a large natural population, resulting in a change in frequency of alleles that confer resistance. While many insecticide resistance variants have been characterized at the gene level, they are typically single genes of large effect identified in highly resistant pest species. In ...
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Individuals vary extensively in the way they respond to disease but the genetic basis of this variation is not fully understood. We found substantial individual variation in resistance and tolerance to the fungal pathogen Metarhizium anisopliae Ma549 using the Drosophila melanogaster Genetic Reference Panel (DGRP). In addition, we found that host defense to Ma549 was correlated with defense to ...
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We used 197 Drosophila melanogaster Genetic Reference Panel (DGRP) lines to perform a genome-wide association analysis for virgin female lifespan, using ~2M common single nucleotide polymorphisms (SNPs). We found considerable genetic variation in lifespan in the DGRP, with a broad-sense heritability of 0.413. There was little power to detect signals at a genome-wide level in single-SNP and gene...
متن کاملChromosomal Analyses of the Genetic Factors for Resistance to Ddt in Two Resistant Lines of Drosophila Melanogaster.
melanogaster all pointed to the conclusion that resistance was inherited not a3 a single gene but as a polygenic complex. Numerous resistant lines had been produced by selection. In some the mean tolerance had been increased more than twentyfold. But response to selection was always slow and it was as rapid at a relatively low level of selective intensity when only the most susceptible half of ...
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BACKGROUND Moderate to high DDT resistance in generally associated with overexpression of multiple genes and therefore has been considered to be polygenic. However, very little information is available about the molecular mechanisms that insect populations employ when evolving increased levels of resistance. The presence of common regulatory motifs among resistance-associated genes may help to ...
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ژورنال
عنوان ژورنال: Genetics
سال: 2017
ISSN: 1943-2631
DOI: 10.1534/genetics.117.300310