Inotropic therapy of the failing myocardium
نویسندگان
چکیده
منابع مشابه
Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium.
BACKGROUND Contrary to beta(1)- and beta(2)-adrenoceptors, beta(3)-adrenoceptors mediate a negative inotropic effect in human ventricular muscle. To assess their functional role in heart failure, our purpose was to compare the expression and contractile effect of beta(3)-adrenoceptors in nonfailing and failing human hearts. METHODS AND RESULTS We analyzed left ventricular samples from 29 fail...
متن کاملUpregulation of b3-Adrenoceptors and Altered Contractile Response to Inotropic Amines in Human Failing Myocardium
Background—Contrary to b1and b2-adrenoceptors, b3-adrenoceptors mediate a negative inotropic effect in human ventricular muscle. To assess their functional role in heart failure, our purpose was to compare the expression and contractile effect of b3-adrenoceptors in nonfailing and failing human hearts. Methods and Results—We analyzed left ventricular samples from 29 failing (16 ischemic and 13 ...
متن کاملInsulin-Like Growth Factor-1 Exerts Ca-Dependent Positive Inotropic Effects in Failing Human Myocardium
Myocardial generation of insulin-like growth factor-1 (IGF-1) is altered in hypertrophy and heart failure, but there are no reports on acute functional effects of IGF-1 in human cardiac muscle. We examined inotropic responses and signal transduction mechanisms of IGF-1 in human myocardium. Experiments were performed in isolated trabeculae or cardiomyocytes from 46 end-stage failing hearts. The ...
متن کاملInsulin Causes [Ca ]i-Dependent and [Ca ]i-Independent Positive Inotropic Effects in Failing Human Myocardium
Background—Insulin has been shown to exert positive inotropic effects in several in vitro and in vivo models, but signal transduction and substrate dependency remain unclear. We examined inotropic responses and signal transduction mechanisms of insulin in human myocardium. Methods and Results—Experiments were performed in isolated trabeculae from end-stage failing hearts of 58 nondiabetic and 3...
متن کاملInsulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium.
Myocardial generation of insulin-like growth factor-1 (IGF-1) is altered in hypertrophy and heart failure, but there are no reports on acute functional effects of IGF-1 in human cardiac muscle. We examined inotropic responses and signal transduction mechanisms of IGF-1 in human myocardium. Experiments were performed in isolated trabeculae or cardiomyocytes from 46 end-stage failing hearts. The ...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 1993
ISSN: 0160-9289,1932-8737
DOI: 10.1002/clc.4960160103