منابع مشابه
Do pyrotechnics contain radium?
Many pyrotechnic devices contain barium nitrate which is used as an oxidizer and colouring agent primarily for green-coloured fireworks. Similarly, strontium nitrate is used for red-coloured pyrotechnic effects. Due to their chemical similarities to radium, barium and strontium ores can accumulate radium, causing a remarkable activity in these minerals. Radium in such contaminated raw materials...
متن کاملAnalysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis
The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds. Inositol pyrophosphates regulate diverse biological processes and are attracting attention due to their ability to control energy metabolism and insulin signalling. However, inositol pyrophosphat...
متن کاملInositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair*
Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP(7)), are water-soluble inositol phosphates that contain high energy diphosphate moieties on the inositol ring. Inositol hexakisphosphate kinase 1 (IP6K1) participates in inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6)) to IP(7). In the present study, we show that mouse embryonic fibroblasts (M...
متن کاملGene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.
Inositol pyrophosphates, also designated inositol diphosphates, possess high-energy beta-phosphates that can pyrophosphorylate proteins and regulate various cellular processes. They are formed by a family of inositol hexakisphosphate kinases (IP6Ks). We have created mice with a targeted deletion of IP6K1 in which production of inositol pyrophosphates is markedly diminished. Defects in the mutan...
متن کاملA High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors
Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches. Probe development frequently begins with a high-throughput screen (HTS) of a chemical library. Herein, we describe the design, validation, and implementation of the first HTS-compatible strategy against any inositol phosphate kinase. Our ta...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2007
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2007.04.008