Innentitelbild: Capturing Elusive Cobaltacycle Intermediates: A Real-Time Snapshot of the Cp*CoIII -Catalyzed Oxidative Alkyne Annulation (Angew. Chem. 40/2017)
نویسندگان
چکیده
منابع مشابه
Nickel-catalyzed alkyne annulation by anilines: versatile indole synthesis by C-H/N-H functionalization.
Versatile nickel catalysts enabled the step-economical synthesis of decorated indoles through alkyne annulations with anilines bearing removable directing groups. The C-H/N-H activation strategy efficiently occurred in the absence of any metal oxidants and with excellent selectivities.
متن کاملCapturing the elusive aromaticity of bicalicene.
The ring-current aromaticity of the bicalicene molecule arises, in spite of the 16 π carbon perimeter, from strong local diatropic circulations on the two pentagonal rings, as shown by current-density maps computed at the ipsocentric RHF/6-311G** and DFT/6-311G** levels of theory. Conjugated-circuit models cannot capture this pattern of circulation as it arises from 'ionic' contributions in a v...
متن کاملCu-catalyzed azide-alkyne cycloaddition.
The Huisgen 1,3-dipolar cycloaddition reaction of organic azides and alkynes has gained considerable attention in recent years due to the introduction in 2001 of Cu(1) catalysis by Tornøe and Meldal, leading to a major improvement in both rate and regioselectivity of the reaction, as realized independently by the Meldal and the Sharpless laboratories. The great success of the Cu(1) catalyzed re...
متن کاملIsolation of bis(copper) key intermediates in Cu-catalyzed azide-alkyne “click reaction”
The copper-catalyzed 1,3-dipolar cycloaddition of an azide to a terminal alkyne (CuAAC) is one of the most popular chemical transformations, with applications ranging from material to life sciences. However, despite many mechanistic studies, direct observation of key components of the catalytic cycle is still missing. Initially, mononuclear species were thought to be the active catalysts, but l...
متن کاملSilver-catalyzed synthesis of 4-substituted benzofurans via a cascade oxidative coupling-annulation protocol.
A facile synthesis of 4-indole benzofurans from the one-pot reaction of 4-alkyl-2-ynylphenols and indoles via a hypervalent iodine-induced oxidative dearomatization, a silver-catalyzed cascade Michael addition-annulation, and an aromatization is reported.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2017
ISSN: 0044-8249
DOI: 10.1002/ange.201707433