منابع مشابه
On the Role of the Innate Immunity in Autoimmune Disease
The essence of the immune system is built on two separate foundation pillars: one is specific or adaptive immunity which is characterized by relatively slow response kinetics and the ability to remember. The other is nonspecific or innate immunity exhibiting rapid response kinetics but lacking memory. Lymphocytes are the key players of the adaptive immune system. Each lymphocyte expresses antig...
متن کاملInnate Immunity and Cardiometabolic Disease
Innate Immunity and Cardiometabolic Disease Innate immunity, an ancient form of host defense, is the body’s rapid, first-line response to environmental threats, such as microbial infection. In contrast to the adaptive immune system—which is present only in higher-order vertebrates, and mediated primarily by somatically generated receptors—the innate immune system relies inherently on basic dete...
متن کاملOsteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases
Osteopontin (OPN) regulates the immune response at multiple levels. Physiologically, it regulates the host response to infections by driving T helper (Th) polarization and acting on both innate and adaptive immunity; pathologically, it contributes to the development of immune-mediated and inflammatory diseases. In some cases, the mechanisms of these effects have been described, but many aspects...
متن کاملInnate immunity and alcoholic liver disease.
Innate immunity provides the primary response to danger signals from pathogens or injured host cells and tissues. The cells of the innate immune system include monocytes, macrophages, dendritic cells, neutrophils, NK cells and NKT cells that orchestrate innate immune and initiate adaptive immune responses via cell interactions, cytokines, chemokines and other mediators. The most robust and comm...
متن کاملInflammatory bowel disease related innate immunity and adaptive immunity.
Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn's disease (CD). Its pathogenesis remains not yet clear. Current researchers believe that after environmental factors act on individuals with genetic susceptibility, an abnormal intestinal immune response is launched under stimulation of intestinal flora. However...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2016
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.105.747