“Inject-Mix-React-Separate-and-Quantitate” (IMReSQ) Method for Screening Enzyme Inhibitors
نویسندگان
چکیده
منابع مشابه
"Inject-mix-react-separate-and-quantitate" (IMReSQ) method for screening enzyme inhibitors.
Many regulatory enzymes are considered attractive therapeutic targets, and their inhibitors are potential drug candidates. Screening combinatorial libraries for enzyme inhibitors is pivotal to identifying hit compounds for the development of drugs targeting regulatory enzymes. Here, we introduce the first inhibitor screening method that consumes only nanoliters of the reactant solutions and is ...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2008
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja804544x