Inhibitory SMADs: Potential Regulators of Ovarian Function1
نویسندگان
چکیده
منابع مشابه
Inhibitory Smads and TGF- Signaling in Glomerular Cells
Smad6 and Smad7 are inhibitory SMADs with putative functional roles at the intersection of major intracellular signaling networks, including TGF, receptor tyrosine kinase (RTK), JAK/STAT, and NFB pathways. This study reports differential functional roles and regulation of Smad6 and Smad7 in TGFsignaling in renal cells, in murine models of renal disease and in human glomerular diseases. Smad7 is...
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Smad ubiquitin regulatory factor (Smurf) 1 binds to receptor-regulated Smads for bone morphogenetic proteins (BMPs) Smad1/5 and promotes their degradation. In addition, Smurf1 associates with transforming growth factor-beta type I receptor through the inhibitory Smad (I-Smad) Smad7 and induces their degradation. Herein, we examined whether Smurf1 negatively regulates BMP signaling together with...
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Transforming Growth Factor (TGF)-β family, including TGF-β, bone morphorgenic protein (BMP), and activn, plays an important role in essential cellular functions such as proliferation, differentiation, apoptosis, tissue remodeling, angiognesis, immune responses, and cell adhesions. TGF-β predominantly transmits the signals through serine/ threonine receptor kinases and cytoplasmic proteins calle...
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Transforming growth factor β (TGF-β) family signaling dictates highly complex programs of gene expression responses, which are extensively regulated at multiple levels and vary depending on the physiological context. The formation, activation, and destruction of two major functional complexes in the TGF-β signaling pathway (i.e., the TGF-β receptor complexes and the Smad complexes that act as c...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2015
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.114.125203