Inhibitory effects of PGD2, PGJ2 AND 15-deoxy-Δ12,14 -PGJ2 on iNOS induction in rat mesenteric artery
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چکیده
منابع مشابه
Biosynthesis of 15-deoxy-∆-PGJ2 and the ligation of PPARγ
945 Introduction The PPAR nuclear hormone transcription factors heterodimerize with retinoic acid receptors to regulate expression of distinct gene cassettes (1, 2). Although three PPAR isotypes (α, δ, and γ) have been well characterized, the identity of their natural ligands remains controversial (3–6). PPARγ is expressed predominantly in adipose tissue, colon and macrophages, and to a lesser ...
متن کاملEffects of 15-Deoxy-Δ12,14-Prostaglandin J2 (15d-PGJ2) and Rosiglitazone on Human Vδ2+ T Cells
BACKGROUND Thiazolidinediones (TZD) class of drugs, and 15-deoxy-D12,14-prostaglandin J2 (15d-PGJ2) are immune regulators predicted to modulate human autoimmune disease. Their effects on gammadelta T cells, which are involved in animal model and human and animal autoimmune diseases, are unknown. METHODOLOGY/PRINCIPAL FINDINGS We characterized the activity of rosiglitazone (from the TZD class ...
متن کاملStimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2.
Nerve growth factor (NGF) has recently been shown to be secreted from white adipocytes, its production being strongly stimulated by the proinflammatory cytokine tumor necrosis factor-alpha. In this study, we have examined whether a series of prostaglandins and other inflammation-related factors also stimulate NGF expression and secretion by adipocytes, using 3T3-L1 cells. Although interleukin (...
متن کامل15-deoxy-Δ12,14-PGJ2 promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis
BACKGROUND Prostaglandins (PGs), lipid autacoids derived from arachidonic acid, play a pivotal role during inflammation. PGD₂ synthase is abundantly expressed in heart tissue and PGD₂ has recently been found to induce cardiomyocyte apoptosis. PGD₂ is an unstable prostanoid metabolite; therefore the objective of the present study was to elucidate whether its final dehydration product, 15-deoxy-Δ...
متن کاملProstaglandin D2 inhibits inducible nitric oxide synthase expression in rat vascular smooth muscle cells.
Vascular smooth muscle cells (VSMCs) as well as macrophages have been shown to generate a substantial amount of NO in inflammatory vascular lesions. Prostaglandin (PG) D2 (PGD2) is produced by inflammatory cells, including mast cells and macrophages. We investigated whether PGD2 modulates NO metabolism in rat VSMCs. PGD2 at a concentration of 10(-7) mol/L or greater dose-dependently inhibited n...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2000
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)48284-x