Inhibitory Effects of Myrrha Water Extract on Atopic Dermatitis Related Chemokines in HaCaT Cells

Due to high therapeutic potentials of natural products, the use medicinal plants is highlighted treat various inflammationmediated diseases. Myrrha have been used as a traditional remedy infectious and inflammatory But, its effects mechanisms anti atopic dermatitis (AD) not elucidated. The aim this study evaluate anti-allergic antiinflammatory water extract Myrrha, in cell models also suggest putative mechanism AD actions Myrrha. HaCaT cells were pre-treated with for 1 h stimulated tumor necrosis factor-alpha (TNF-α) interferon-gamma (IFN- γ) (10 ng/mL each). After 24 h, harvested To expression Th2 chemokines, such C-C motif chemokine ligand 5 (CCL5, known RANTES), 17 (CCL17, TARC) 22 (CCL22, MDC). investigate regulatory we assessed phosphorylation signal transducer activator transcription (STAT1) signaling pathways cells. Treatment decreased mRNA levels RANTES, TARC MDC concentration dependent manner. In addition, significantly reduced TNF-α IFN-γ induced STAT1. This could indicate that shows activity mainly through Thus, propose may be promising skin protector, which clinical basis cosmetics development.